解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Macroautophagy/autophagy involves the formation of an autophagosome, a double-membrane vesicle that delivers sequestered cytoplasmic cargo to lysosomes for degradation and recycling. Closely related, endocytosis mediates the sorting and transport of cargo throughout the cell, and both processes are important for cellu...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2017.1356976
更新日期:2017-10-03 00:00:00
abstract::Overcoming metabolic stress is a critical step in tumorigenesis. Acetyl coenzyme A (acetyl-CoA) converted from glucose or acetate is a substrate used for histone acetylation to regulate gene expression. However, how acetyl-CoA is produced under nutritional stress conditions is unclear. Herein we report that nutritiona...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2017.1349581
更新日期:2017-10-03 00:00:00
abstract::Induced pluripotent stem cells (iPSCs) have fewer and immature mitochondria than somatic cells and mainly rely on glycolysis for energy source. During somatic cell reprogramming, somatic mitochondria and other organelles get remodeled. However, events of organelle remodeling and interaction during somatic cell reprogr...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2017.1338545
更新日期:2017-09-02 00:00:00
abstract::This Editor's Corner may sound like the title of a mystery novel, but it actually reflects a question I have about the puncta articles that appear in Autophagy (or rather, the ones that do not appear). In particular, I am surprised by the number of solicitations sent out for puncta that are either ignored, or, less fr...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2017.1349043
更新日期:2017-09-02 00:00:00
abstract::Oxidative stress-induced granulosa cell (GCs) death represents a common reason for follicular atresia. Follicle-stimulating hormone (FSH) has been shown to prevent GCs from oxidative injury, although the underlying mechanism remains to be elucidated. Here we first report that the suppression of autophagic cell death v...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2017.1327941
更新日期:2017-08-03 00:00:00
abstract::Macroautophagy/autophagy is a dynamic and inducible catabolic process that responds to a variety of hormonal and environmental cues. Recent studies highlight the interplay of this central pathway in a variety of pathophysiological diseases. Although defective autophagy is implicated in melanocyte proliferation and pig...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2017.1327509
更新日期:2017-08-03 00:00:00
abstract::Although the treatments of malignant glioma include surgery, radiotherapy and chemotherapy by oral drug administration, the prognosis of patients with glioma remains very poor. We developed a polyethylene glycol-dipalmitoylphosphatidyle- thanoiamine (mPEG-DPPE) calcium phosphate nanoparticles (NPs) injectable thermore...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2017.1320634
更新日期:2017-07-03 00:00:00
abstract::In yeast and mammals, selective vacuolar delivery and degradation of whole mitochondria, or mitophagy, represents an important quality control system and is achieved by a cargo recognition mechanism enabling selective elimination of dysfunctional mitochondria. As photosynthetic organelles that need light for energy pr...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2017.1310360
更新日期:2017-07-03 00:00:00
abstract::Non-small cell lung cancer (NSCLC) often metastasizes to the brain, but identifying which patients will develop brain metastases (BM) is difficult. Macroautophagy/autophagy is critical for cancer initiation and progression. We hypothesized that genetic variants of autophagy-related genes may affect brain metastases (B...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2017.1308997
更新日期:2017-06-03 00:00:00
abstract::SPHK1 (sphingosine kinase 1), a regulator of sphingolipid metabolites, plays a causal role in the development of hepatocellular carcinoma (HCC) through augmenting HCC invasion and metastasis. However, the mechanism by which SPHK1 signaling promotes invasion and metastasis in HCC remains to be clarified. Here, we repor...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2017.1291479
更新日期:2017-05-04 00:00:00
abstract::The upregulation of autophagosome formation in response to nutrient deprivation requires significant intracellular membrane rearrangements that are poorly understood. Recent findings have implicated COPII-coated vesicles, well known as ER-Golgi cargo transport carriers, as key players in macroautophagy. The role of CO...
journal_title:Autophagy
pub_type: 杂志文章,评审
doi:10.1080/15548627.2017.1287657
更新日期:2017-05-04 00:00:00
abstract::Accumulating evidence has demonstrated that macroautophagy/autophagy plays an essential role in self-renewal and differentiation in embryonic hematopoiesis. Here, according to the RNA sequencing data sets of 5 population cells related to hematopoietic stem cell (HSC) formation during mouse embryogenesis (endothelial c...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2016.1278093
更新日期:2017-04-03 00:00:00
abstract::Heme is an essential molecule expressed in many tissues where it plays key roles as the prosthetic group of several proteins involved in vital physiological and metabolic processes such as gas and electron transport. Structurally, heme is a tetrapyrrole ring containing an atom of iron (Fe) in its center. When released...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2016.1271515
更新日期:2017-03-04 00:00:00
abstract::The master regulator of lysosome biogenesis, TFEB, is regulated by MTORC1 through phosphorylation at S211, and a S211A mutation increases nuclear localization. However, TFEBS211A localizes diffusely in both cytoplasm and nucleus and, as we show, retains regulation by MTORC1. Here, we report that endogenous TFEB is pho...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2016.1271514
更新日期:2017-03-04 00:00:00
abstract::Autophagy and apoptosis are 2 fundamental biological mechanisms that may cooperate or be antagonistic, although both are involved in deciding the fate of cells in physiological or pathological conditions. These 2 mechanisms coexist simultaneously in cells and share common upstream signals and stimuli. Autophagy and ap...
journal_title:Autophagy
pub_type: 杂志文章,评审
doi:10.1080/15548627.2016.1256522
更新日期:2017-03-04 00:00:00
abstract::Atg13 is an essential subunit of the Atg1 autophagy initiation complex in yeast and its mammalian counterpart, ATG13, is indispensable for autophagy induction by the ULK1 complex. The N terminus of the protein folds into a HORMA domain, an architecture that has been revealed by crystallography. 1-4 In human cells, the...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2016.1277312
更新日期:2017-03-04 00:00:00
abstract::Formation of metastases, also known as cancer dissemination, is an important stage of breast cancer (BrCa) development. KISS1 expression is associated with inhibition of metastases development. Recently we have demonstrated that BrCa metastases to the brain exhibit low levels of KISS1 expression at both mRNA and prote...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2017.1360466
更新日期:2017-01-01 00:00:00
abstract::Protein misfolding is the common theme for neurodegenerative disorders including Huntington disease (HD), which is mainly caused by cytotoxicity of the mutant HTT (huntingtin) protein (mHTT). The soluble mHTT has an expanded polyglutamine (polyQ) stretch that may adopt multiple conformations, among which the one recog...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2017.1382783
更新日期:2017-01-01 00:00:00
abstract::Macroautophagy/autophagy is an intracellular stress survival and recycling system whereas phagocytosis internalizes material from the extracellular milieu; yet, both pathways utilize lysosomes for cargo degradation. Whereas autophagy occurs in all cells, phagocytosis is performed by cell types such as macrophages and ...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2017.1380124
更新日期:2017-01-01 00:00:00
abstract::Pathological developments leading to amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are associated with misbehavior of several key proteins, such as SOD1 (superoxide dismutase 1), TARDBP/TDP-43, FUS, C9orf72, and dipeptide repeat proteins generated as a result of the translation of th...
journal_title:Autophagy
pub_type: 杂志文章,评审
doi:10.1080/15548627.2017.1384889
更新日期:2017-01-01 00:00:00
abstract::One of the main unanswered questions regarding the early steps of macroautophagy/autophagy is the mechanism of membrane-modeling events required for autophagosome formation. Three independent studies have recently revealed an actin cytoskeleton involvement in this process, providing significant details regarding the r...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2016.1236877
更新日期:2016-12-01 00:00:00
abstract::A pilot clinical trial based on nutritional modulation was designed to assess the efficacy of a one-year low-protein diet in activating autophagy in skeletal muscle of patients affected by COL6/collagen VI-related myopathies. Ullrich congenital muscular dystrophy and Bethlem myopathy are rare inherited muscle disorder...
journal_title:Autophagy
pub_type: 临床试验,杂志文章
doi:10.1080/15548627.2016.1231279
更新日期:2016-12-01 00:00:00
abstract::Autophagy helps to maintain cellular homeostasis by removing misfolded proteins and damaged organelles, and generally acts as a cytoprotective mechanism for neuronal survival. Here we showed that mice deficient in the Vici syndrome gene Epg5, which is required for autophagosome maturation, show accumulation of ubiquit...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2016.1238554
更新日期:2016-12-01 00:00:00
abstract::We have previously shown that Kaposi sarcoma-associated herpesvirus (KSHV) impairs monocyte differentiation into dendritic cells (DCs). Macroautophagy/autophagy has been reported to be essential in such a differentiating process. Here we extended these studies and found that the impairment of DC formation by KSHV occu...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2016.1235122
更新日期:2016-12-01 00:00:00
abstract::A coding polymorphism of the critical autophagic effector ATG16L1 (T300A) increases the risk of Crohn disease, but how this mutation influences the function of ATG16L1 has remained unclear. In a recent report, we showed that the A300 allele alters the ability of the C-terminal WD40 domain of ATG16L1 to interact with p...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2016.1216303
更新日期:2016-11-01 00:00:00
abstract::The N-terminal amino acid of a protein is an essential determinant of ubiquitination and subsequent proteasomal degradation in the N-end rule pathway. Using para-chloroamphetamine (PCA), a specific inhibitor of the arginylation branch of the pathway (Arg/N-end rule pathway), we identified that blocking the Arg/N-end r...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2016.1222991
更新日期:2016-11-01 00:00:00
abstract::Prion protein modulates many cellular functions including the secretion of trophic factors by astrocytes. Some of these factors are found in exosomes, which are formed within multivesicular bodies (MVBs) and secreted into the extracellular space to modulate cell-cell communication. The mechanisms underlying exosome bi...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2016.1226735
更新日期:2016-11-01 00:00:00
abstract::Autophagy, a catabolic pathway of lysosomal degradation, acts not only as an efficient recycle and survival mechanism during cellular stress, but also as an anti-infective machinery. The human pathogen Staphylococcus aureus (S. aureus) was originally considered solely as an extracellular bacterium, but is now recogniz...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2016.1226732
更新日期:2016-11-01 00:00:00
abstract::Chronic lung inflammation is accepted as being associated with the development of lung cancer caused by nickel exposure. Therefore, identifying the molecular mechanisms that lead to a nickel-induced sustained inflammatory microenvironment that causes transformation of human bronchial epithelial cells is of high signif...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2016.1196313
更新日期:2016-10-02 00:00:00
abstract::Damaged mitochondria are turned over through a process of selective autophagy termed mitophagy. In mitophagy, unhealthy mitochondria are recognized and ubiquitinated by Parkinson disease-linked proteins PINK1 and PARK2. The subsequent recruitment of ubiquitin-binding autophagy receptors leads in turn to the sequestrat...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2016.1212788
更新日期:2016-10-02 00:00:00
abstract::Proteins in eukaryotic cells are continually being degraded to amino acids either by the ubiquitin proteasome system (UPS) or by the autophagic-lysosomal pathway. The breakdown of proteins by these 2 degradative pathways involves totally different enzymes that function in distinct subcellular compartments. While most ...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2016.1205770
更新日期:2016-10-02 00:00:00
abstract::In humans, loss of TBC1D20 (TBC1 domain family, member 20) protein function causes Warburg Micro syndrome 4 (WARBM4), an autosomal recessive disorder characterized by congenital eye, brain, and genital abnormalities. TBC1D20-deficient mice exhibit ocular abnormalities and male infertility. TBC1D20 is a ubiquitously ex...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2016.1199300
更新日期:2016-10-02 00:00:00
abstract::BBC3 (BCL2 binding component 3) is a known apoptosis inducer; however, its role in microglial survival remains poorly understood. In addition to the classical transcription factor TRP53, Mir143 is involved in BBC3 expression at the post-transcriptional level. Here, we identify unique roles of Mir143-BBC3 in mediating ...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2016.1191723
更新日期:2016-09-01 00:00:00
abstract::Phagocytosis plays a central role in immunity and tissue homeostasis. After internalization of cargo into single-membrane phagosomes, these compartments undergo a maturation sequences that terminates in lysosome fusion and cargo degradation. Components of the autophagy pathway have recently been linked to phagosome ma...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2016.1191724
更新日期:2016-09-01 00:00:00
abstract::Ultraviolet (UV)-induced DNA damage is a major risk factor for skin cancers including melanoma. UVRAG, originally identified to complement UV sensitivity in xeroderma pigmentosum (XP), has since been implicated in modulating macroautophagy/autophagy, in coordinating different intracellular trafficking pathways, and in...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2016.1196319
更新日期:2016-09-01 00:00:00
abstract::As a selective degradation system, chaperone-mediated autophagy (CMA) is essential for maintaining cellular homeostasis and survival under stress conditions. Increasing evidence points to an important role for the dysfunction of CMA in the pathogenesis of Parkinson disease (PD). However, the mechanisms by which CMA re...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2016.1179401
更新日期:2016-08-02 00:00:00
abstract::Autophagy is a highly conserved intracellular degradation system, and recently was shown to display circadian rhythms in mice. The mechanisms underlying circadian regulation of autophagy, however, are still unclear. Here, we observed that numbers of autophagosomes and autolysosomes exhibit daily rhythms in the zebrafi...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2016.1183843
更新日期:2016-08-02 00:00:00
abstract::The molecular mechanism of macroautophagy/autophagy induction has been intensively studied, but little is known about downregulation of autophagy and how this process is restricted. In particular, how is autophagy maintained at an appropriate homeostatic level when cells are subjected to prolonged stress? In this stud...
journal_title:Autophagy
pub_type: 评论,社论
doi:10.1080/15548627.2016.1173802
更新日期:2016-07-02 00:00:00
abstract::Understanding the role of autophagy in cancer has been limited by the inability to measure this dynamic process in formalin-fixed tissue. We considered that 3-dimensional models including ex vivo tumor, such as we have developed for studying mesothelioma, would provide valuable insights. Using these models, in which w...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2016.1173799
更新日期:2016-07-02 00:00:00
abstract::Autophagy is a process of bulk protein degradation and organelle turnover, and is a current therapeutic target in several diseases. The present study aimed to clarify the significance of myocardial autophagy of patients with dilated cardiomyopathy (DCM). Left ventricular endomyocardial biopsy was performed in 250 cons...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2016.1145326
更新日期:2016-01-01 00:00:00